Up-to-date publications are also available on:
Research Articles 2026 Superpixel-ComBat multi-site harmonization of unpaired T1W MRI data in Huntington’s disease
Annabelle Coleman, Chang-Le Chen , Joelle Hanson-Baiden, Davneet Minhas, ..., and Lauren Byrne
NeuroImage: Reports , 2026
Peer-reviewed
Differential cerebral white matter tract alterations in generalized anxiety disorder revealed by ultra-high-field 7 T diffusion-weighted imaging
Chang-Le Chen , Minjie Wu, Yueyang Chi, Max Rose, ..., Howard Aizenstein, and Shaolin Yang
Journal of Affective Disorders , 2026
Peer-reviewed
Longitudinal Changes of the White Matter Microstructural Properties of Autism Spectrum Disorder: A Normative Model Analysis
Yi-Ling Chien, Wan-Ling Tseng, Chang-Le Chen , Wen-Yih Isaac Tseng, and Susan Shur-Fen Gau
Autism Research , 2026
Peer-reviewed
Neurology and inflammatory‐associated plasma protein biomarkers linked to dementia progression, brain aging pathology
Noah Schweitzer, Sang Joon Son, Bistra Iordanova, Nicholas Fitz, Ana Costa, Jinghang Li, Chang-Le Chen , ..., and Minjie Wu
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring , 2026
Peer-reviewed
2025 Periventricular diffusivity reflects APOE ε4–modulated amyloid accumulation and cognitive impairment in the Alzheimer’s disease continuum
Chang-Le Chen , Sang Joon Son, Noah Schweitzer, Hecheng Jin, Jinghang Li, Linghai Wang, Shaolin Yang, ..., and Minjie Wu
Alzheimer’s & Dementia , 2025
Peer-reviewed
Influence of dehydroepiandrosterone sulphate levels on the slower age-related decline in grey matter in younger women with polycystic ovary syndrome
Mei-Jou Chen, Chang-Le Chen , Yu-Yuan Chang, Chu-Chun Huang, Wen-Chau Wu, Hong-Nerng Ho, and Wen-Yih Isaac Tseng
Brain Communications , 2025
Peer-reviewed
2024 Superpixel-ComBat modeling: A joint approach for harmonization and characterization of inter-scanner variability in T1-weighted images
Chang-Le Chen , Mahbaneh Eshaghzadeh Torbati, Davneet S Minhas, Charles M Laymon, Seong Jae Hwang, Murat Bilgel, Adina Crainiceanu, Hecheng Jin, ..., and Dana L Tudorascu
Imaging Neuroscience , 2024
Peer-reviewed
Advanced brain aging in Parkinson’s disease with cognitive impairment
Chang-Le Chen , Shao-Ying Cheng, Leila Montaser-Kouhsari, Wen-Chao Wu, Yung-Chin Hsu, Chun-Hwei Tai, Wen-Yih Isaac Tseng, Ming-Che Kuo, and Ruey-Meei Wu
npj Parkinson’s Disease , 2024
Peer-reviewed
Sex-specific risk factors and clinical dementia outcomes for white matter hyperintensities in a large South Korean cohort
Noah Schweitzer, Sang Joon Son, Rebecca C Thurston, Jinghang Li, Chang-Le Chen , Howard Aizenstein, ..., and Minjie Wu
Alzheimer’s Research & Therapy , 2024
Peer-reviewed
Machine-learning-based feature selection to identify attention-deficit hyperactivity disorder using whole-brain white matter microstructure: A longitudinal study
Huey-Ling Chiang, Chi-Shin Wu, Chang-Le Chen , Wen-Yih Isaac Tseng, and Susan Shur-Fen Gau
Asian Journal of Psychiatry , 2024
Peer-reviewed
2023 MISPEL: A supervised deep learning harmonization method for multi-scanner neuroimaging data
Mahbaneh Eshaghzadeh Torbati, Davneet S Minhas, Charles M Laymon, Pauline Maillard, James D Wilson, Chang-Le Chen , Ciprian M Crainiceanu, Charles S DeCarli, Seong Jae Hwang, and Dana L Tudorascu
Medical image analysis , 2023
Peer-reviewed
Atypical development in white matter microstructures in ADHD: A longitudinal diffusion imaging study
Huey-Ling Chiang, Wen-Yih Isaac Tseng, Wan-Ling Tseng, Yu-Hung Tung, Yung-Chin Hsu, Chang-Le Chen , and Susan Shur-Fen Gau
Asian journal of psychiatry , 2023
Peer-reviewed
2022 Detection of advanced brain aging in schizophrenia and its structural underpinning by using normative brain age metrics
Chang-Le Chen , Tzung‐Jeng Hwang, Yu-Hung Tung, Li-Ying Yang, Yung-Chin Hsu, Chih‐Min Liu, Yi-Tin Lin, Ming-Hsien Hsieh, Chen-Chung Liu, ..., and Wen-Yih Isaac Tseng
NeuroImage: Clinical , 2022
Peer-reviewed
Validation of neuroimaging-based brain age gap as a mediator between modifiable risk factors and cognition
Chang-Le Chen , Ming-Che Kuo, Pin-Yu Chen, Yu-Hung Tung, Yung-Chin Hsu, Chi-Wen Christina Huang, Wing P Chan, and Wen-Yih Isaac Tseng
Neurobiology of Aging , 2022
Peer-reviewed
Advanced brain aging in multiple system atrophy compared to Parkinson’s disease
Chang-Le Chen , Ming-Che Kuo, Wen-Chau Wu, Yung-Chin Hsu, Ruey-Meei Wu, and Wen-Yih Isaac Tseng
NeuroImage: Clinical , 2022
Peer-reviewed
Neurodevelopmental model of schizophrenia revisited: similarity in individual deviation and idiosyncrasy from the normative model of whole-brain white matter tracts and shared brain-cognition covariation with ADHD and ASD
Yi-Ling Chien, Hsiang-Yuan Lin, Yu-Hung Tung, Tzung-Jeng Hwang, Chang-Le Chen , ..., and Susan Shur-Fen Gau
Molecular psychiatry , 2022
Peer-reviewed
2021 Whole brain white matter tract deviation and idiosyncrasy from normative development in autism and ADHD and unaffected siblings link with dimensions of psychopathology and cognition
Yu-Hung Tung, Hsiang-Yuan Lin, Chang-Le Chen , Chi-Yung Shang, Li-Ying Yang, Yung-Chin Hsu, Wen-Yih Isaac Tseng, and Susan Shur-Fen Gau
American Journal of Psychiatry , 2021
Peer-reviewed
Microstructural differences in white matter tracts across middle to late adulthood: a diffusion MRI study on 7167 UK Biobank participants
Wen-Yih Isaac Tseng, Yung-Chin Hsu, Chang-Le Chen , Yun-Jing Kang, Te-Wei Kao, Pin-Yu Chen, and Gordon D Waiter
Neurobiology of Aging , 2021
Peer-reviewed
Differential associations of white matter brain age with language-related mechanisms in word-finding ability across the adult lifespan
Pin-Yu Chen, Chang-Le Chen , Hui-Ming Tseng, Yung-Chin Hsu, Chi-Wen Christina Huang, Wing P Chan, and Wen-Yih I Tseng
Frontiers in Aging Neuroscience , 2021
Peer-reviewed
2020 Generalization of diffusion magnetic resonance imaging–based brain age prediction model through transfer learning
Chang-Le Chen , Yung-Chin Hsu, Li-Ying Yang, Yu-Hung Tung, Wen-Bin Luo, Chih-Min Liu, Tzung-Jeng Hwang, Hai-Gwo Hwu, and Wen-Yih Isaac Tseng
NeuroImage , 2020
Peer-reviewed
Fluid intelligence is associated with cortical volume and white matter tract integrity within multiple-demand system across adult lifespan
Pin-Yu Chen, Chang-Le Chen , Yung-Chin Hsu, and Wen-Yih I Tseng
NeuroImage , 2020
Peer-reviewed
2019 Premature white matter aging in patients with right mesial temporal lobe epilepsy: A machine learning approach based on diffusion MRI data
Chang-Le Chen , Yao-Chia Shih, Horng-Huei Liou, Yung-Chin Hsu, Fa-Hsuan Lin, and Wen-Yih Isaac Tseng
NeuroImage: Clinical , 2019
Peer-reviewed
Sustained modulation of emotion-related fibers after 8 weeks of mindfulness-based stress reduction training
Chang-Le Chen , Yao-Chia Shih, Yung-Chin Hsu, Tzung-Kuen Wen, Shih-Chin Fang, Da-Lun Tang, Si-Chen Lee, and Wen-Yih Isaac Tseng
bioRxiv , 2019
Preprint
